More specifically, the proposed LIT mechanisms of action includes a humoral response with the production of anti-idiotype and asymmetric-blocking antibodies preventing maternal rejection of the fetus. This involves stimulating the maternal immune system to produce antibodies such as Anti-paternal cytotoxic antibody (APCA), Ab2, anti-T cell receptor (TCR) idiotypic antibodies, MLR-Bf, and progesterone-induced blocking factor (PIBF). These antibodies help prevent the maternal immune system, particularly T and NK cells, from recognizing paternal HLA antigens by blocking these antigens. Additionally, LIT is reported to reduce NK cell activity, downregulate the expression of maternal IL-2 receptors, shift the immune response toward Th1, improve the Th1/Th2 balance, and increase Treg responses over Th17 responses.